轴突中含有轴向细胞骨架，负责将合成于神经元胞体内、含有神经递质的囊泡运输到轴突末端的突触前膜。
但就在今天，一项发表于《自然-神经科学》的最新研究试图改写人们对轴突形态的根本认知。来自约翰·霍普金斯大学医学院与加州大学圣地亚哥分校的研究团队在显微图像中发现，哺乳动物的轴突是由一个个形似珍珠的囊泡均匀地串联而成，就像是一根纳米级的珍珠手链！一个更具颠覆性的观点是，这些“珍珠”可能还会影响动作电位的传导速度。
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对于第二个问题，这项研究得出了更加有趣而大胆的结论：轴突形态可能会直接调节动作电位的传导速度。当研究团队去除了神经元膜上的胆固醇后，小鼠轴突的珍珠状结构减少了，轴突传导动作电位的速度也随之减慢。研究指出，由于胆固醇具有多重作用，因此轴突形态可能不是唯一的贡献因素，但这项研究还是提出了一种全新的神经元可塑性范式：生物物理因素的调节影响轴突纳米珍珠化，从而控制动作电位传导速度。
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神经元是神经系统的基本功能单位，负责接收、处理和传递信息。在神经元的结构中，轴突、树突和突触是最关键的三个组成部分，它们共同协作，确保神经信号的高效传递。本文将详细探讨这三者的结构、功能以及它们之间的相互关系。
为此，研究团队使用高压冷冻技术来处理不同的小鼠神经元样本，包括在实验室培养皿中生长的神经元、从成年小鼠以及小鼠胚胎中提取的神经元切片。研究作者指出，这项技术可以更好地保存细胞的精细结构。需要指出的是，这些神经元轴突没有最外层的髓鞘包裹，由此避免了髓鞘对轴突形态的限制。
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